Main Article Content

Abstract

Chymotrypsin like protease is a ratified target in the design of potential anticoronavirus inhibitor. In a recent research conducted by TCS, India 31 molecules out of 1600000 have been identified as the most effective protease inhibitors against COVID 19. One of those is Aurantiamide, a plant constituent derived from ‘Piper aurantiacum‘, mostly available in India, Nepal, Vietnam, Thailand and other Asian countries. Still the process is under in vitro state. This “Aurantiamide” in the form of Aurantiamide acetate has anti-cancer, anti-inflammatory and antinociceptive activities as yet traced. The combined application of Hydroxychloroquine and Azithromycin is reported as a treatment of COVID 19 till now. This article is on the usage of Piper Betel leaf as a potential herbal medicine to grow human body’s self defence mechanism against either the reception of such pathogens or in viral load reduction of affected patients.

Keywords

Betel Piper COVID19 Herbal Medicine

Article Details

Citations
Sengupta, P. S. (2020). Use of Piper Betel to combat COVID19. [email protected] - Preprint Archive, 1(1). https://doi.org/10.36375/prepare_u.a92

References

  1. Satyal, Prabodh & Setzer, William. (2012). Chemical Composition and Biological Activities of Nepalese Piper BetelL. International Journal of Professional Holistic Aromatherapy.
  2. Mustofar, N & Ahmed, Nor & Azelan, N & Awang, Mohd & Aziz, Azila & Aziz, R. & Taher, Z & Zolkopli, N. (2017). Optimization of CCD Analysis of Hydroxychavicol from Piper Beetle L. leaves.
  3. Biochemical Characterization of Selected Plant Species and Investigation of Phytochemicals for In-Vitro Antioxidant Activity *Sindhu.S.Nair, Nithyakala C.M, Ronilla.V. Rozario, Jennifer. J, Somashekharaiah B.V; International Journal of Pharmacognosy and Phytochemical Research 2012; 4(3); 127-133
  4. Antioxidant Activity of Piper Betel Leaf Extract and Its Constituents by Jitesh S. Rathe, Birija S. Patro, Soumyaditya Mula, Sunita Gamre, Subrata Chattopadhyay; Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India
  5. Rutugandha Paranjpe, Sushma R. Gundala, N. Lakshminarayana, Arpana Sagwal, Ghazia Asif, Anjali Pandey, Ritu Aneja, Piper Betel leaf extract: anticancer benefits and bio-guided fractionation to identify active principles for prostate cancer management, Carcinogenesis, Volume 34, Issue 7, July 2013, Pages 1558–1566, https://doi.org/10.1093/carcin/bgt066
  6. Piper Betel L.: A Review of Phytochemical and Pharmacological Profile by Sonia Saini; International Education And Research Journal
  7. Piper Betel Leaf: A Reservoir of Potential Xenohormetic Nutraceuticals with Cancer-Fighting Properties by Sushma R. Gundala and Ritu Aneja; Cancer Prevention Research, AACR
  8. Alam, MD Badrul & Akter, Fahima & Parvin, Nahida & Pia, Rashna & Akter, Sharmin & Chowdhury, Jesmin & Sifath-E-Jahan, Kazi & Haque, Ekramul. (2013). Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper Betel leaves. Avicenna journal of phytomedicine. 3. 112-25.
  9. Antioxidant and antimicrobial potential of selected varieties of Piper Betel L. (Betel leaf) by Chayanika Sarma, Prasad Rasane, Sawinder Kaur, Jyoti Singh, Joginder Singh, Yogesh Gat, Umar Garba, Damanpreet Kaur, Kajal Dhawan; An. Acad. Bras. Ciênc. vol.90 no.4 Rio de Janeiro out./dez. 2018 Epub 18-Out-2018
  10. Muangthai, Pornpimol & Ditsayamontri, Patcharapun & Tumtamai, Nutchanard & Uaroon, Thanawan. (2017). Efficacy of Betel Leaf Extracts as Antioxidant in Moisturizing Cream. Journal of Life Sciences. 11. 10.17265/1934-7391/2017.02.005.
  11. Betel Leaf – The Green Gold S.Sripradha Saveetha Dental College, Chennai
  12. Rathee JS, Patro BS, Mula S, Gamre S, Chattopadhyay S. Antioxidant activity of Piper Betel leaf extract and its constituents. J Agric Food Chem. 2006 Nov29;54(24):9046-54. PubMed PMID: 17117789.
  13. A. Syahidah, C.R. Saad, M.D. Hassan, Y. Rukayadi, M.H. Norazian and M.S. Kamarudin, 2017. Phytochemical Analysis, Identification and Quantification of Antibacterial Active Compounds in Betel Leaves, Piper Betel Methanolic Extract. Pakistan Journal of Biological Sciences, 20: 70-81. https://scialert.net/abstract/?doi=pjbs.2017.70.81
  14. Extraction of Betel leaves (Piper Betel L.) essential oil and its bio-actives identification: Process optimization, GC-MS analysis and anti-microbial activity Author: Mitali Madhumita, Proshanta Guha, Ahindra Nag, Publication: Industrial Crops and Products
  15. Prabhu MS, Platel K, Saraswathi G, Srinivasan K. Effect of orally administered Betel leaf (Piper Betel Linn.) on digestive enzymes of pancreas and intestinal mucosa and on bile production in rats. Indian J Exp Biol. 1995 Oct;33(10):752-6. PubMed PMID: 8575807
  16. Pradhan, Deepak &Suri, K.A. &Pradhan, D.K. & Biswasroy, P.. (2013). Golden Heart of the Nature: Piper BetelL..J Pharmacog Phytochem. 1. 147-167.
  17. Antinociceptive Activities of Aqueous and Ethanol Extracts of Piper Betel. Leaves in Rats by L.S.R. Arambewela, ,L.D.A.M. Arawwawala& W.D. Ratnasooriya
  18. Ferland, Catherine & Beaudry, Francis & Vachon, Pascal. (2012). Antinociceptive Effects of Eugenol Evaluated in a Monoiodoacetate-induced Osteoarthritis Rat Model.Phytotherapy research : PTR. 26. 1278-85. 10.1002/ptr.3725.
  19. Ethnobotany of the genus Piper (Piperaceae) in Thailand by Arunrat Chaveerach, Piya Mokkamul, Runglawan Sudmoon, and Tawatchai Tanee; Ethnobotany Research & Applications 4:223-231 (2006)
  20. Dyer, Lee & Richards, Joe & Dodson, Craig. (2004). Isolation Synthesis and Evolutionary Ecology of Piper Amides. A Model Genus for Studies of Phytochemistry, Ecology, and Evolution. 9. 10.1007/978-0-387-30599-8_7.
  21. The Medicinal Plant Industry By R. O. B. Wijesekera
  22. Antioxidant Activity of Piper Betel Leaf Extract and Its Constituent by Jitesh S. Rathee, Birija S. Patro, Soumyaditya Mula, Sunita Gamre, and Subrata Chattopadhyay. Journal of Agricultural and Food Chemistry 2006 54 (24), 9046-9054DOI: 10.1021/jf061679e
  23. Review study on potential activity of Piper Betel- Vandana Dwivedi, ShaliniTripathi Journal of Pharmacognosy and Phytochemistry 2014; 3(4): 93-98
  24. Eugenol – U.S. National Library of Medicine, National Center For Biotechnology Information
  25. Studies on wild edible plants of ethnic people in east Sikkim Savita*, Lokendra Singh, Preeti Vats and Saima Parveen Department of Botany, Meerut College, Meerut - 250 110 (U.P.) India
  26. Control of pain with topical plant medicines by James David Adams Jr., Xiaogang Wang; University of Southern California, School of Pharmacy, Los Angeles, CA, USA
  27. Betel Leaf: A Source of Ingredients having Potential to Combat Influenza by Prashant Kumar*Amity Institute of Virology and Immunology, Amity University Uttar Pradesh, Noida, India .Acta Scientific Microbiology (ISSN: 2581-3226), Volume 1 Issue 6 June 2018.
  28. The coronavirus has thick spikes that seem to latch more easily onto human cells than other viruses, according to a 3D map of its structure by Shira Feder, Business Insider, Mar 31, 2020, 02:26 IST, https://www.businessinsider.in/science/news/the-coronavirus-has-thick-spikes-that-seem-to-latch-more-easily-onto-human-cells-than-other-viruses-according-to-a-3d-map-of-its-structure/articleshow/74903010.cms
  29. Berry, M., Fielding, B. & Gamieldien, J. Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies. BMC Struct Biol 15, 8 (2015).https://doi.org/10.1186/s12900-015-0035-3
  30. Bioactive compounds from medicinal plants: Focus on Piper species by E.E. Mgbeahuruike, T. Yrjönen, H. Vuorela, Y. Holm; University of Helsinki, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, P.O. Box 56, FI-00014, University of Helsinki, Finland; South African Journal of Botany; Volume 112, September 2017.
  31. Al-Adhroey, Abdulelah & Nor, Zurainee & Al-Mekhlafi, Hesham & Amran, Adel & Mahmud, Rohela.(2011). Antimalarial Activity of Methanolic Leaf Extract of Piper Betel L. Molecules (Basel, Switzerland). Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur & Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda, Abdul Aziz, Kuala Lumpur 50300, Malaysia; 16.107-18. 10.3390/molecules16010107
  32. Eugenol—From the Remote Maluku Islands to the International Market Place: A Review of a Remarkable and Versatile Molecule by Guy P. Kamatou, Ilze Vermaakand Alvaro M. Viljoen *Department of Pharmaceutical Sciences, Faculty of Science, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa. Molecules 2012, 17(6), 6953-6981; https://doi.org/10.3390/molecules17066953
  33. Ubey, Kriti & Anand, Bibin & Shekhawat, Dolat & Kar, Karunakar. (2017). Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis. Scientific Reports. 7. 40744. 10.1038/srep40744.
  34. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Author: Philippe Gautret, Jean-Christophe Lagier, Philippe Parola, Hoang, Line Meddeb, Morgane Mailhe, Barbara Doudier, Johan Courjon,Valérie Giordanengo, Vera Esteves Vieira, Hervé Tissot Dupont, Stéphane Honoré, Philippe Colson, Eric Chabrière et al; Publication: International Journal of Antimicrobial Agents; Publisher: Elsevier; Date: Available online 20 March 2020
  35. Fonsêca, Diogo & Salgado, Paula & Neto, Humberto & Golzio, Adriana & Filho, Marcelo & Melo, Cynthia & Leite, Fagner & Piuvezam, Marcia & Pordeus, Liana & Barbosa Filho, Jose & Almeida, Reinaldo. (2016). Ortho-eugenol exhibits anti-nociceptive and anti-inflammatory activities. International immunopharmacology. 38. 402-408. 10.1016/j.intimp.2016.06.005.
  36. Ferland, Catherine &Beaudry, Francis & Vachon, Pascal. (2012). Antinociceptive Effects of Eugenol Evaluated in a Monoiodoacetate-induced Osteoarthritis Rat Model. Phytotherapy research: PTR. 26. 1278-85. 10.1002/ptr.3725.
  37. Crystallization of SARS Coronavirus 3CL Protease to Identify Inhibitor Targets by Samantha Zinnia Fernandes, Brandon Anson, and Andrew Mesecar, https://www.fasebj.org/doi/abs/10.1096/fasebj.2019.33.1_supplement.493.4
  38. Piper Betel Leaf: A Reservoir of Potential Xenohormetic Nutraceuticals with Cancer-Fighting Properties by Sushma R. Gundala and Ritu Aneja; Published Online First January 21, 2014; DOI: 10.1158/1940-6207.CAPR-13-0355
  39. Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications by Bahare Salehi, Zainul Amiruddin Zakaria, Rabin Gyawali, Salam A. Ibrahim, Jovana Rajkovic, Zabta Khan Shinwari, Tariq Khan, Javad Sharifi-Rad, Adem Ozleyen, ElifTurkdonmez, Marco Valussi, Tugba Boyunegmez Tumer, Lianet Monzote Fidalgo, Miquel Martorell, William N. Setzer Molecules. 2019 Apr; 24(7): 1364. Published online 2019 Apr 7.doi: 10.3390/molecules24071364; PMCID: PMC6479398
  40. Piper Betel Linn. A maligned Pan-Asiatic plant with an array of pharmacological activities and prospects for drug discovery by Nikhil Kumar, Pragya Mishra, Anuradha Dube, Shailja Bhattacharya, Madhu Dikshit and Shirish Ranade; Beetle Vine Biotechnology and Plant Molecular Biology Divisions, National Botanical Research Institute, Lucknow & Division of Parasitology and Division of Pharmacology, Central Drug Research institute, Lucknow, India
  41. Piper Betel leaf – Topic by science.gov